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Molecules 2018, 23(5), 1133; https://doi.org/10.3390/molecules23051133

Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles

1
Department of Chemistry, Faculty of Science, King Faisal University, Hofuf 31982, Saudi Arabia
2
Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-suef 62514, Egypt
3
Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
*
Author to whom correspondence should be addressed.
Received: 4 April 2018 / Revised: 7 May 2018 / Accepted: 7 May 2018 / Published: 10 May 2018
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Abstract

Small heterocyclic compounds containing nitrogen and sulfur atoms, such as thiazole derivatives, represent a significant class of organic azoles that exhibit promising bioactivities and have a great potential in medicinal and agricultural fields. A convenient and high-yielding synthetic approach for a range of organic molecules is presented. The nuclease-like activities of compounds were studied with the aid of E. coli AB1157 DNA and agarose gel electrophoresis. The antioxidant evaluation of the compounds was carried out with different antioxidant techniques, such as ABTS and NO scavenging efficiency. The antibacterial behavior was evaluated against various bacterial strains, both Gram-positive and -negative, and the minimum inhibitory concentration (MIC) values of these compounds were determined. The antiproliferative activities and IC50 values of the synthesized organic molecules compounds against HEPG-2, MCF-7, and HCT-116 cell lines were evaluated. View Full-Text
Keywords: hydrazonoyl; thiosemicarbazones; thiazoles; polythiazoles; DNA degradation; antioxidant; antimicrobial; IC50 hydrazonoyl; thiosemicarbazones; thiazoles; polythiazoles; DNA degradation; antioxidant; antimicrobial; IC50
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Al-Omair, M.A.; Sayed, A.R.; Youssef, M.M. Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles. Molecules 2018, 23, 1133.

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