Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles
AbstractSmall heterocyclic compounds containing nitrogen and sulfur atoms, such as thiazole derivatives, represent a significant class of organic azoles that exhibit promising bioactivities and have a great potential in medicinal and agricultural fields. A convenient and high-yielding synthetic approach for a range of organic molecules is presented. The nuclease-like activities of compounds were studied with the aid of E. coli AB1157 DNA and agarose gel electrophoresis. The antioxidant evaluation of the compounds was carried out with different antioxidant techniques, such as ABTS and NO scavenging efficiency. The antibacterial behavior was evaluated against various bacterial strains, both Gram-positive and -negative, and the minimum inhibitory concentration (MIC) values of these compounds were determined. The antiproliferative activities and IC50 values of the synthesized organic molecules compounds against HEPG-2, MCF-7, and HCT-116 cell lines were evaluated. View Full-Text
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Al-Omair, M.A.; Sayed, A.R.; Youssef, M.M. Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles. Molecules 2018, 23, 1133.
Al-Omair MA, Sayed AR, Youssef MM. Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles. Molecules. 2018; 23(5):1133.Chicago/Turabian Style
Al-Omair, Mohammed A.; Sayed, Abdelwahed R.; Youssef, Magdy M. 2018. "Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles." Molecules 23, no. 5: 1133.
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