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Molecules 2018, 23(5), 1122; https://doi.org/10.3390/molecules23051122

In Vitro Anticandidal Activity and Mechanism of a Polyoxovanadate Functionalized by Zn-Fluconazole Complexes

1
School of Public Health, Jilin University, Changchun 130021, China
2
College of Basic Medical Science, Jilin University, Changchun 130021, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 13 April 2018 / Revised: 25 April 2018 / Accepted: 3 May 2018 / Published: 9 May 2018
(This article belongs to the Section Inorganic Chemistry)
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Abstract

The rise in the number of fungal infections is requiring the rapid development of novel antifungal agents. A new polyoxovanadate functionalized by Zn-fluconazole coordination complexes, Zn3(FLC)6V10O28·10H2O (ZnFLC) (FLC = fluconazole) has been synthesized and evaluated for in vitro antifungal against Candida species. The identity of ZnFLC were confirmed by elemental analysis, IR spectrum, and single-crystal X-ray diffraction. The antifungal activities of ZnFLC was screened in 19 Candida species strains using the microdilution checkerboard technique. The minimum inhibitory concentration (MIC80) value of ZnFLC is 4 μg/mL on the azole-resistant clinical isolates of C. albicans HL973, which is lower than the positive control, FLC. The mechanism of ZnFLC against C. albicans HL973 showed that ZnFLC damaged the fungal cell membrane and reduced the ergosterol content. The expression of ERG1, ERG7, ERG11 ERG27, and ERG28, which have effects on the synthesis of ergosterol, were all significantly upregulated by ZnFLC. View Full-Text
Keywords: polyoxovanadate; fluconazole; antifungal activity; ergosterol; rt-PCR polyoxovanadate; fluconazole; antifungal activity; ergosterol; rt-PCR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guo, S.; Yang, W.; Zhao, M.; Tian, R.; Zhang, B.; Qi, Y. In Vitro Anticandidal Activity and Mechanism of a Polyoxovanadate Functionalized by Zn-Fluconazole Complexes. Molecules 2018, 23, 1122.

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