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Molecules 2018, 23(5), 1078; https://doi.org/10.3390/molecules23051078

Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity

1
Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
2
School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Author to whom correspondence should be addressed.
Received: 30 March 2018 / Revised: 19 April 2018 / Accepted: 27 April 2018 / Published: 3 May 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Three new highly oxygenated (24), and two known (1 and 5) germacranolides, were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configuration of 1 was established using the circular dichroism (CD) method and X-ray diffraction, and the stereochemistry of the new compounds 24 were determined using similar CD spectra with 1. The new compound 2 and the known compound 5 exhibited potent cytotoxicity against hepatocellular cancer (Hep G2) and human cervical cancer (HeLa) cells, superior to those of the positive control cis-platin. View Full-Text
Keywords: Carpesium divaricatum; germacranolides; absolute configuration; cytotoxicity Carpesium divaricatum; germacranolides; absolute configuration; cytotoxicity
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Zhang, T.; Si, J.-G.; Zhang, Q.-B.; Chen, J.-H.; Ding, G.; Zhang, H.-W.; Jia, H.-M.; Zou, Z.-M. Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity. Molecules 2018, 23, 1078.

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