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Molecules 2018, 23(4), 926; https://doi.org/10.3390/molecules23040926

Biflavonoids Isolated from Selaginella tamariscina and Their Anti-Inflammatory Activities via ERK 1/2 Signaling

1
College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon-si 57922, Jeonnam, Korea
2
Research Institute of Life and Pharmaceutical Sciences, 255 Jungangno, Suncheon-si 57922, Jeonnam, Korea
*
Author to whom correspondence should be addressed.
Received: 9 March 2018 / Revised: 11 April 2018 / Accepted: 13 April 2018 / Published: 17 April 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Selaginella tamariscina (S. tamariscina) (Beauv.) Spring (Selaginellaceae) has been used in oriental medicine for the treatment of dysmenorrhea, chronic hepatitis, hyperglycemia, amenorrhea, hematuria, prolapse of the anus and metrorrhagia. In the present study, we isolated two strong anti-inflammatory compounds, the biflavonoids hinokiflavone (H) and 7′-O-methyl hinokiflavone (mH), from S. tamariscina and examined their anti-inflammatory activities in lipopolysaccharide (LPS)-mediated murine macrophages (RAW 264.7) and colon epithelial cells (HT-29). H and mH suppressed the production of the inflammatory mediators nitric oxide (NO), interleukin (IL)-6, IL-8, and tumor-necrosis factor (TNF)-α, which are most highly activated in inflammatory bowel disease (IBD). In addition, Western blot analysis revealed that H and mH suppressed the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2, and the activation of nuclear factor-κB (NF-κB) and extracellular regulated kinases (ERK) 1/2. These results suggest that H and mH are compounds having potent anti-inflammatory effects that could be used to treat such diseases as IBD. View Full-Text
Keywords: Selaginella tamariscina; hinokiflavone; 7′-O-methyl hinokiflavone; RAW 264.7 cells; HT-29 cells Selaginella tamariscina; hinokiflavone; 7′-O-methyl hinokiflavone; RAW 264.7 cells; HT-29 cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Shim, S.-Y.; Lee, S.-G.; Lee, M. Biflavonoids Isolated from Selaginella tamariscina and Their Anti-Inflammatory Activities via ERK 1/2 Signaling. Molecules 2018, 23, 926.

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