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Molecules 2018, 23(4), 855; doi:10.3390/molecules23040855

Tricycloalternarene Analogs from a Symbiotic Fungus Aspergillus sp. D and Their Antimicrobial and Cytotoxic Effects

1
School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
2
College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310038, China
*
Author to whom correspondence should be addressed.
Received: 19 March 2018 / Revised: 3 April 2018 / Accepted: 5 April 2018 / Published: 9 April 2018
(This article belongs to the Special Issue Biological Activity of Secondary Metabolites)
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Abstract

Bioassay-guided fractionation of the crude extract of fermentation broth of one symbiotic strain Aspergillus sp. D from the coastal plant Edgeworthia chrysantha Lindl. led to isolation of one new meroterpenoid, tricycloalternarene 14b (1), together with four known analogs (25), tricycloalternarenes 2b (2), 3a (3), 3b (4), and ACTG-toxin F (5). Their chemical structures were unambiguously established on the basis of NMR, mass spectrometry, and optical rotation data analysis, as well as by comparison with literature data. Biological assays indicated that compound 2 exhibited potent in vitro cytotoxicity against human lung adenocarcinoma A549 cell line with an IC50 value of 2.91 μM, and compound 5 had a moderate inhibitory effect on Candida albicans, with an MIC value of 15.63 μM. The results indicated that this symbiotic strain D is an important producer of tricycloalternarene derivatives, with potential therapeutic application in treatment of cancer and pathogen infection. View Full-Text
Keywords: tricycloalternarene; meroterpenoid; Aspergillus sp.; Edgeworthia chrysantha Lindl.; symbiotic microbe; coastal plant tricycloalternarene; meroterpenoid; Aspergillus sp.; Edgeworthia chrysantha Lindl.; symbiotic microbe; coastal plant
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Zhang, H.; Zhao, Z.; Chen, J.; Bai, X.; Wang, H. Tricycloalternarene Analogs from a Symbiotic Fungus Aspergillus sp. D and Their Antimicrobial and Cytotoxic Effects. Molecules 2018, 23, 855.

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