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Molecules 2018, 23(4), 774; https://doi.org/10.3390/molecules23040774

In Vitro Anti-Toxoplasma gondii and Antimicrobial Activity of Amides Derived from Cinnamic Acid

1
Laboratório de Ciências Químicas, Centro de Ciências e Tecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000—Parque Califórnia, 28013-602 Campos dos Goytacazes/RJ, Brazil
2
Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000—Parque Califórnia, 28013-602 Campos dos Goytacazes/RJ, Brazil
3
Laboratório de Sanidade Animal, Centro de Ciências e Tecnologias Agropecuárias, Universidade Estadual do Norte Fluminense-Darcy Ribeiro, Av. Alberto Lamego, 2000—Parque Califórnia, 28013-602 Campos dos Goytacazes/RJ, Brazil
*
Author to whom correspondence should be addressed.
Received: 1 March 2018 / Revised: 19 March 2018 / Accepted: 23 March 2018 / Published: 28 March 2018
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Abstract

Most cinnamic acids, their esters, amides, aldehydes, and alcohols present several therapeutic actions through anti-inflammatory, antitumor, and inhibitory activity against a great variety of microorganisms. In this work, eight amines derived from cinnamic acid were synthesized and tested against host cells infected with Toxoplasma gondii and the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, and three strains of Staphylococcus aureus. Compounds 3 and 4 showed the best result against intracellular T. gondii, presenting antiparasitic activity at low concentrations (0.38 and 0.77 mM). The antibacterial activity of these compounds was also evaluated by the agar microdilution method, and amides 2 and 5 had a minimum inhibitory concentration of 250 µg mL−1 against two strains of S. aureus (ATCC 25923 and bovine strain LSA 88). These also showed synergistic action along with a variety of antibiotics, demonstrating that amines derived from cinnamic acid have potential as pharmacological agents. View Full-Text
Keywords: synthetic amides; antiparasitic; antibiotic; acrylamides synthetic amides; antiparasitic; antibiotic; acrylamides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Silveira, G.R.; Campelo, K.A.; Lima, G.R.S.; Carvalho, L.P.; Samarão, S.S.; Vieira-da-Motta, O.; Mathias, L.; Matos, C.R.R.; Vieira, I.J.C.; Melo, E.J.T.; Maria, E.J. In Vitro Anti-Toxoplasma gondii and Antimicrobial Activity of Amides Derived from Cinnamic Acid. Molecules 2018, 23, 774.

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