Recent Advances in Zirconium-89 Chelator Development
AbstractThe interest in zirconium-89 (89Zr) as a positron-emitting radionuclide has grown considerably over the last decade due to its standardized production, long half-life of 78.2 h, favorable decay characteristics for positron emission tomography (PET) imaging and its successful use in a variety of clinical and preclinical applications. However, to be utilized effectively in PET applications it must be stably bound to a targeting ligand, and the most successfully used 89Zr chelator is desferrioxamine B (DFO), which is commercially available as the iron chelator Desferal®. Despite the prevalence of DFO in 89Zr-immuno-PET applications, the development of new ligands for this radiometal is an active area of research. This review focuses on recent advances in zirconium-89 chelation chemistry and will highlight the rapidly expanding ligand classes that are under investigation as DFO alternatives. View Full-Text
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Bhatt, N.B.; Pandya, D.N.; Wadas, T.J. Recent Advances in Zirconium-89 Chelator Development. Molecules 2018, 23, 638.
Bhatt NB, Pandya DN, Wadas TJ. Recent Advances in Zirconium-89 Chelator Development. Molecules. 2018; 23(3):638.Chicago/Turabian Style
Bhatt, Nikunj B.; Pandya, Darpan N.; Wadas, Thaddeus J. 2018. "Recent Advances in Zirconium-89 Chelator Development." Molecules 23, no. 3: 638.
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