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Molecules 2018, 23(3), 624; https://doi.org/10.3390/molecules23030624

Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections

1
IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
2
Consiglio per la Ricerca in Agricoltura e L’analisi Dell’economia Agraria, Centro di Ricerca Agricoltura e Ambiente (CREA-AA), Via di Corticella 133, 40128 Bologna, Italy
3
Institute of Organic and Analytical Chemistry (ICOA), Université d’Orléans et the French National Center for Scientific Research (CNRS), UMR 7311, BP 6759, F-45067 Orléans, France
*
Author to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 3 March 2018 / Accepted: 3 March 2018 / Published: 9 March 2018
(This article belongs to the Special Issue Focusing on Sulfur in Medicinal Chemistry)
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Abstract

The use of plant-derived products as antimicrobial agents has been investigated in depth. Isothiocyanates (ITCs) are bioactive products resulting from enzymatic hydrolysis of glucosinolates (GLs), the most abundant secondary metabolites in the botanical order Brassicales. Although the antimicrobial activity of ITCs against foodborne and plant pathogens has been well documented, little is known about their antimicrobial properties against human pathogens. This review collects studies that focus on this topic. Particular focus will be put on ITCs’ antimicrobial properties and their mechanism of action against human pathogens for which the current therapeutic solutions are deficient and therefore of prime importance for public health. Our purpose was the evaluation of the potential use of ITCs to replace or support the common antibiotics. Even though ITCs appear to be effective against the most important human pathogens, including bacteria with resistant phenotypes, the majority of the studies did not show comparable results and thus it is very difficult to compare the antimicrobial activity of the different ITCs. For this reason, a standard method should be used and further studies are needed. View Full-Text
Keywords: isothiocyanates (ITCs); allyl isothiocyanate (AITC); benzyl isothiocyanate (BITC); phenyl isothiocyanate (PITC); phenyl ethyl isothiocyanate (PEITC); sulforaphane (SFN); moringin (MGN); microbial infection; antibiotics isothiocyanates (ITCs); allyl isothiocyanate (AITC); benzyl isothiocyanate (BITC); phenyl isothiocyanate (PITC); phenyl ethyl isothiocyanate (PEITC); sulforaphane (SFN); moringin (MGN); microbial infection; antibiotics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Romeo, L.; Iori, R.; Rollin, P.; Bramanti, P.; Mazzon, E. Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections. Molecules 2018, 23, 624.

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