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Molecules 2018, 23(3), 553; https://doi.org/10.3390/molecules23030553

Thermogelling 3D Systems towards Stem Cell-Based Tissue Regeneration Therapies

1
Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China
2
Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore 4558, Queensland, Australia
3
A*STAR (Agency for Science, Technology and Research), Institute of Materials Science and Engineering, 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore
*
Authors to whom correspondence should be addressed.
Received: 4 January 2018 / Revised: 25 February 2018 / Accepted: 26 February 2018 / Published: 2 March 2018
(This article belongs to the Special Issue Functional Molecular Materials)
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Abstract

Stem cell culturing and differentiation is a very important research direction for tissue engineering. Thermogels are well suited for encapsulating cells because of their non-biotoxic nature and mild sol-gel transition as temperature increases. In particular, thermogels provide a 3D growth environment for stem cell growth, which is more similar to the extracellular matrix than flat substrates, so thermogels as a medium can overcome many of the cell abnormalities caused by 2D cell growth. In this review, we summarize the applications of thermogels in cell and stem cell culture in recent years. We also elaborate on the methods to induce stem cell differentiation by using thermogel-based 3D scaffolds. In particular, thermogels, encapsulating specific differentiation-inducing factor and having specific structures and moduli, can induce the differentiation into the desired tissue cells. Three dimensional thermogel scaffolds that control the growth and differentiation of cells will undoubtedly have a bright future in regenerative medicine. View Full-Text
Keywords: thermogel; 3D culture; stem cell; tissue engineering thermogel; 3D culture; stem cell; tissue engineering
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Wang, X.; Young, D.J.; Wu, Y.-L.; Loh, X.J. Thermogelling 3D Systems towards Stem Cell-Based Tissue Regeneration Therapies. Molecules 2018, 23, 553.

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