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Molecules 2018, 23(2), 491; https://doi.org/10.3390/molecules23020491

Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells

1
Department of Pharmacy, People’s Liberation Army Institute of Chinese Medicine, Beijing 100039, China
2
People's Liberation Army Institute of Organ Transplantation, Beijing 100091, China
3
Academy of Mongolian Medicine, Inner Mongolia Medical University, Hohhot 010110, China
4
Institute of Materia Medica, School of Pharmacy, The Fourth Military Medical University, Xi’an 710032, China
The authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 6 February 2018 / Revised: 17 February 2018 / Accepted: 21 February 2018 / Published: 23 February 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Five previously undescribed triterpenoid saponins (15), along with eight known ones (613), were isolated from the whole plants of Anemone rivularis var. flore-minore. Their structures were clarified by extensive spectroscopic data and chemical evidence. For the first time, the lupane-type saponins (3 and 12) were reported from the Anemone genus. The anti-proliferative activity of all isolated saponins was evaluated on hepatic stellate cells (HSC-T6). Saponins 12 and 13, which possess more monosaccharides than the others, displayed potent anti-proliferative activity, with IC50 values of 18.21 and 15.56 μM, respectively. View Full-Text
Keywords: Triterpenoid saponins; Anemone rivularis var. flore-minore; Anti-proliferative activity; HSC-T6 Triterpenoid saponins; Anemone rivularis var. flore-minore; Anti-proliferative activity; HSC-T6
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, X.-Y.; Gao, H.; Xie, X.-J.; Jurhiin, J.; Zhang, M.-Z.-H.; Zhou, Y.-P.; Liu, R.; Ning, M.; Han, J.; Tang, H.-F. Triterpenoid Saponins from Anemone rivularis var. Flore-Minore and Their Anti-Proliferative Activity on HSC-T6 Cells. Molecules 2018, 23, 491.

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