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Molecules 2018, 23(2), 414; https://doi.org/10.3390/molecules23020414

Antibacterial Peptides in Dermatology–Strategies for Evaluation of Allergic Potential

1
Department of Embryology, Medical University of Gdańsk, 80-211 Gdansk, Poland
2
Department of Clinical Immunology and Transplantology, Medical University of Gdańsk, 80-211 Gdansk, Poland
3
Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, 80-308 Gdansk, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 20 January 2018 / Revised: 9 February 2018 / Accepted: 13 February 2018 / Published: 14 February 2018
(This article belongs to the Special Issue Antimicrobial Peptides and Peptidomimetics)
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Abstract

During recent decades, the market for peptide-based drugs, including antimicrobial peptides, has vastly extended and evolved. These drugs can be useful in treatment of various types of disorders, e.g., cancer, autoimmune diseases, infections, and non-healing wounds. Although peptides are less immunogenic than other biologic therapeutics, they can still induce immune responses and cause allergies. It is important to evaluate the immunogenic and allergic potential of peptides before they are forwarded to the expensive stages of clinical trials. The process of the evaluation of immunogenicity and cytotoxicity is complicated, as in vitro models and bioinformatics tools cannot fully simulate situations in the clinic. Nevertheless, several potentially promising tests for the preclinical evaluation of peptide drugs have been implemented (e.g., cytotoxicity assays, the basophil activation test, and lymphocyte activation assays). In this review, we focus on strategies for evaluation of the allergic potential of peptide-based therapeutics. View Full-Text
Keywords: peptides; antimicrobial peptides; immunogenicity; allergy; toxicity peptides; antimicrobial peptides; immunogenicity; allergy; toxicity
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Deptuła, M.; Wardowska, A.; Dzierżyńska, M.; Rodziewicz-Motowidło, S.; Pikuła, M. Antibacterial Peptides in Dermatology–Strategies for Evaluation of Allergic Potential. Molecules 2018, 23, 414.

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