Next Article in Journal
Synthesis and Fluorescent Property Study of Novel 1,8-Naphthalimide-Based Chemosensors
Next Article in Special Issue
Gold and Nickel Extended Thiophenic-TTF Bisdithiolene Complexes
Previous Article in Journal
Inhibitory Effect of Flavonolignans on the P2Y12 Pathway in Blood Platelets
Previous Article in Special Issue
Outlook on the Application of Metal-Liganded Bioactives for Stimuli-Responsive Release
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(2), 375; https://doi.org/10.3390/molecules23020375

Functional Magnetic Mesoporous Silica Microparticles Capped with an Azo-Derivative: A Promising Colon Drug Delivery Device

1
Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), Polytechnic University of Valencia, University of Valencia, 46100 Valencia, Spain
2
CIBER of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
3
Department of Organic Chemistry, University of Valencia, 46100 Valencia, Spain
4
Engineering Department. Pharmacy and Pharmaceutical Technology Section, Miguel Hernandez University, 03550 Alicante, Spain
5
Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46100 Valencia, Spain
6
Joint Research Unit in Nanomedicine and Sensors. Polytechnic University of Valencia, Health Research Institute Hospital La Fe, 46100 Valencia, Spain.
7
Joint Unit CIPF-UPV of Mechanisms of Diseases and Nanomedicine, Valencia, Polytechnic University of Valencia, Prince Felipe Research Center, 46100 Valencia, Spain
*
Author to whom correspondence should be addressed.
Received: 15 January 2018 / Revised: 31 January 2018 / Accepted: 8 February 2018 / Published: 10 February 2018
(This article belongs to the Special Issue Coordination Chemistry for Devices and Functional Materials)
Full-Text   |   PDF [3480 KB, uploaded 10 February 2018]   |  

Abstract

Magnetic micro-sized mesoporous silica particles were used for the preparation of a gated material able to release an entrapped cargo in the presence of an azo-reducing agent and, to some extent, at acidic pH. The magnetic mesoporous microparticles were loaded with safranin O and the external surface was functionalized with an azo derivative 1 (bearing a carbamate linkage) yielding solid S1. Aqueous suspensions of S1 at pH 7.4 showed negligible safranin O release due to the presence of the bulky azo derivative attached onto the external surface of the inorganic scaffold. However, in the presence of sodium dithionite (azoreductive agent), a remarkable safranin O delivery was observed. At acidic pH, a certain safranin O release from S1 was also found. The pH-triggered safranin O delivery was ascribed to the acid-induced hydrolysis of the carbamate moiety that linked the bulky azo derivatives onto the mesoporous inorganic magnetic support. The controlled release behavior of S1 was also tested using a model that simulated the gastro intestinal tract. View Full-Text
Keywords: magnetic mesoporous silica; azo derivatives; pH triggered; azo reductor; colon release magnetic mesoporous silica; azo derivatives; pH triggered; azo reductor; colon release
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Teruel, A.H.; Coll, C.; Costero, A.M.; Ferri, D.; Parra, M.; Gaviña, P.; González-Álvarez, M.; Merino, V.; Marcos, M.D.; Martínez-Máñez, R.; Sancenón, F. Functional Magnetic Mesoporous Silica Microparticles Capped with an Azo-Derivative: A Promising Colon Drug Delivery Device. Molecules 2018, 23, 375.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top