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Molecules 2018, 23(2), 327; https://doi.org/10.3390/molecules23020327

Synthesis of Two Tetrasaccharide Pentenyl Glycosides Related to the Pectic Rhamnogalacturonan I Polysaccharide

1
Center for Nanomedicine and Theranostics, Technical University of Denmark, Kemitorvet 207, DK-2800 Kgs. Lyngby, Denmark
2
Department of Chemistry, Technical University of Denmark, Kemitorvet 207, DK-2800 Kgs. Lyngby, Denmark
*
Author to whom correspondence should be addressed.
Received: 16 January 2018 / Revised: 29 January 2018 / Accepted: 1 February 2018 / Published: 3 February 2018
(This article belongs to the Special Issue Oligosaccharide Synthesis)
View Full-Text   |   Download PDF [1956 KB, uploaded 3 February 2018]   |  

Abstract

The synthesis of two protected tetrasaccharide pentenyl glycosides with diarabinan and digalactan branching related to the pectic polysaccharide rhamnogalacturonan I is reported. The strategy relies on the coupling of N-phenyl trifluoroacetimidate disaccharide donors to a common rhamnosyl acceptor. The resulting trisaccharide thioglycosides were finally coupled to an n-pentenyl galactoside acceptor to access the two protected branched tetrasaccharides. View Full-Text
Keywords: pectin; rhamnogalacturonan I; branched RG-I; oligosaccharide synthesis pectin; rhamnogalacturonan I; branched RG-I; oligosaccharide synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zakharova, A.N.; Awan, S.I.; Nami, F.; Gotfredsen, C.H.; Madsen, R.; Clausen, M.H. Synthesis of Two Tetrasaccharide Pentenyl Glycosides Related to the Pectic Rhamnogalacturonan I Polysaccharide. Molecules 2018, 23, 327.

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