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Molecules 2018, 23(2), 325; https://doi.org/10.3390/molecules23020325

A Novel Flavonoid Glucoside from the Fruits of Lycium ruthenicun

1
School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China
2
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
3
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
4
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China
*
Authors to whom correspondence should be addressed.
Received: 3 January 2018 / Revised: 23 January 2018 / Accepted: 28 January 2018 / Published: 3 February 2018
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Abstract

A novel flavonoid glucoside, ruthenicunoid A (1), together with eight known substances, were isolated from the fruits of Lycium ruthenicun Murr. Their structures were elucidated by extensive spectroscopic data and chemical methods. Especially, the absolute configuration of glucose residue in 1 was assigned by acid hydrolysis followed by derivatization and GC analysis. Biological evaluation towards Sirtuin 1 (SIRT1) found that compounds 1 and 2 exhibit inhibitory activity against SIRT1 in a concentration-dependent manner, indicating its potential on SIRT1-associated disorders. View Full-Text
Keywords: Lycium ruthenicun; flavonoid; ruthenicunoid A; SIRT1 Lycium ruthenicun; flavonoid; ruthenicunoid A; SIRT1
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Qi, J.-J.; Yan, Y.-M.; Cheng, L.-Z.; Liu, B.-H.; Qin, F.-Y.; Cheng, Y.-X. A Novel Flavonoid Glucoside from the Fruits of Lycium ruthenicun. Molecules 2018, 23, 325.

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