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Molecules 2018, 23(2), 279; https://doi.org/10.3390/molecules23020279

Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27

1
Biotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, Brazil
2
Medicine School, University of Ribeirão Preto, Av. Costábile Romano, 2201, Ribeirão Preto, SP CEP 14096-900, Brazil
3
Laboratory of Green and Medicinal Chemistry, Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, SP CEP 15054-000, Brazil
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 22 December 2017 / Revised: 16 January 2018 / Accepted: 18 January 2018 / Published: 30 January 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy. View Full-Text
Keywords: gastric cancer; curcumin; matrix metalloproteinase 2; migration; invasion; apoptosis gastric cancer; curcumin; matrix metalloproteinase 2; migration; invasion; apoptosis
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Silva, G.; Teixeira Lima, F.; Seba, V.; Mendes Lourenço, A.L.; Lucas, T.G.; de Andrade, B.V.; Torrezan, G.S.; Polaquini, C.R.; Garcia, M.E.; Couto, L.B.; Bestetti, R.B.; de Castro França, S.; Fachin, A.L.; Regasini, L.O.; Marins, M. Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27. Molecules 2018, 23, 279.

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