Biotinylated Cyclooligosaccharides for Paclitaxel Solubilization
AbstractThe poor water solubility of paclitaxel causes significant problems in producing cancer therapeutic formulations. Here, we aimed to solubilize paclitaxel using biocompatible cyclic carbohydrates. Generally recognized as safe, labeled β-cyclodextrin (β-CD), a cyclic α-1,4-glucan consisting of seven glucoses, was prepared, and bio-sourced cyclosophoraoses (CyS), which are unbranched cyclic β-1,2-glucans with 17–23 glucose units, were purified using various chromatographic methods from Rhizobium leguminosarum cultural broth. For effective targeting, CyS and β-CD were modified with a biotinyl moiety in a reaction of mono-6-amino CyS and mono-6-amino-β-CD with N-hydroxysuccinimide ester of biotinamidohexanoic acid. Interestingly, the aqueous solubility of paclitaxel was enhanced 10.3- and 3.7-fold in the presence of biotinyl CyS and biotinyl β-CD, respectively. These findings suggest that biotin-appended cyclooligosaccharides can be applied to improve the delivery of paclitaxel. View Full-Text
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Cho, E.; Jung, S. Biotinylated Cyclooligosaccharides for Paclitaxel Solubilization. Molecules 2018, 23, 90.
Cho E, Jung S. Biotinylated Cyclooligosaccharides for Paclitaxel Solubilization. Molecules. 2018; 23(1):90.Chicago/Turabian Style
Cho, Eunae; Jung, Seunho. 2018. "Biotinylated Cyclooligosaccharides for Paclitaxel Solubilization." Molecules 23, no. 1: 90.
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