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Molecules 2018, 23(1), 87; doi:10.3390/molecules23010087

Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus

1
School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China
2
College of Pharmacy, Wonkwang University, Iksan 570-749, Korea
3
Broad-Ocean Bio-Science and Technique Co., Ltd. of Changsha, Changsha 410205, Hunan, China
4
Department of Oriental Medical Food & Nutrition, Semyung University, Jecheon 27136, Korea
5
School of Pharmacy, KyungHee University, Seoul 130-701, Korea
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 27 December 2017 / Accepted: 29 December 2017 / Published: 1 January 2018
(This article belongs to the Section Natural Products)
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Abstract

The phytochemical study on the leaves of Acanthopanax gracilistylus (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (1), and a new lupane-triterpene glycoside, acangraciliside S (2), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid (3) and acankoreoside C (4). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds 1 and 2 were determined to be 1β,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1β,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28-O-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, 1 and 3, were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production. View Full-Text
Keywords: Acanthopanax gracilistylus; Araliaceae; lupane-triterpene; acangraciligenin S; acangraciliside S Acanthopanax gracilistylus; Araliaceae; lupane-triterpene; acangraciligenin S; acangraciliside S
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, X.-J.; Zou, Q.-P.; Wang, X.; Kim, K.-W.; Lu, M.-F.; Ko, S.-K.; Yook, C.-S.; Kim, Y.-C.; Liu, X.-Q. Lupane Triterpenes from the Leaves of Acanthopanax gracilistylus. Molecules 2018, 23, 87.

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