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Molecules 2018, 23(1), 8; https://doi.org/10.3390/molecules23010008

Recyclable Keggin Heteropolyacids as an Environmentally Benign Catalyst for the Synthesis of New 2-Benzoylamino-N-phenyl-benzamide Derivatives under Microwave Irradiations at Solvent-Free Conditions and the Evaluation of Biological Activity

1
Laboratoire de Chimie Organique Appliquée (Equipe Hétérocycles), Faculté de Chimie, Université des Sciences et de la Technologie Houari Boumediène, BP 32, El-Alia, Bab-Ezzouar 16111, Algeria
2
Laboratoire de Physique et Chimie des Matériaux (LPCM), Université Mouloud Mammeri, BP17RP, Tizi Ouzou 15000, Algeria
3
Laboratoire de Chimie du Gaz Naturel, Faculté de Chimie, Université des Sciences et de la Technologie Houari Boumediène, BP 32, El-Alia, Bab-Ezzouar 16111, Algeria
4
Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal
*
Author to whom correspondence should be addressed.
Received: 19 November 2017 / Revised: 17 December 2017 / Accepted: 20 December 2017 / Published: 21 December 2017
(This article belongs to the Special Issue Chemical Transformation of Renewable Material for Green Chemistry)
View Full-Text   |   Download PDF [967 KB, uploaded 21 December 2017]   |  

Abstract

2-Benzoylamino-N-phenyl-benzamide derivatives (5ah) were prepared from 2-phenyl-3,1-(4H)-benzoxazin-4-one 3 and substituted anilines 4ah in the presence of a Keggin-type heteropolyacids series (H3PW12O40·13H2O; H4SiW12O40·13H2O; H4SiMo12O40·13H2O; and H3PMo12O40·13H2O) as catalysts without solvent and under microwave irradiation. We found that the use of H3PW12O40·13H2O acid coupled to microwave irradiation allowed obtaining a high-yielding reaction with a short time. The compound structures were established by 1H-NMR and 13C-NMR. The antibacterial and antifungal activities of the synthesized compounds exhibited an inhibition of the growth of bacteria and fungi. View Full-Text
Keywords: Keggin-type heteropolyacids; 2-benzoylamino-N-phenyl-benzamide derivatives; microwave irradiation; solvent free conditions; antibacterial; antifungal Keggin-type heteropolyacids; 2-benzoylamino-N-phenyl-benzamide derivatives; microwave irradiation; solvent free conditions; antibacterial; antifungal
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ighilahriz-Boubchir, K.; Boutemeur-Kheddis, B.; Rabia, C.; Makhloufi-Chebli, M.; Hamdi, M.; Silva, A.M.S. Recyclable Keggin Heteropolyacids as an Environmentally Benign Catalyst for the Synthesis of New 2-Benzoylamino-N-phenyl-benzamide Derivatives under Microwave Irradiations at Solvent-Free Conditions and the Evaluation of Biological Activity. Molecules 2018, 23, 8.

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