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Molecules 2018, 23(1), 63; doi:10.3390/molecules23010063

Molecularly Imprinted Microrods via Mesophase Polymerization

1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy
2
Macrofarm s.r.l., c/o Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Rende (CS), Italy
3
Department of Environmental and Chemical Engineering, University of Calabria, 87036 Rende (CS), Italy
4
Faculty of Pharmacy, CAMB, UMR 7199, CNRS-University of Strasbourg, 67400 Illkirch, France
*
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 21 December 2017 / Accepted: 22 December 2017 / Published: 28 December 2017
(This article belongs to the Special Issue Synthesis and Applications of Molecularly Imprinted Polymers)
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Abstract

The aim of the present research work was the synthesis of molecularly imprinted polymers (MIPs) with a rod-like geometry via “mesophase polymerization”. The ternary lyotropic system consisting of sodium dodecyl sulfate (SDS), water, and decanol was chosen to prepare a hexagonal mesophase to direct the morphology of the synthesized imprinted polymers using theophylline, methacrylic acid, and ethylene glycol dimethacrylate as a drug model template, a functional monomer, and a crosslinker, respectively. The obtained molecularly imprinted microrods (MIMs) were assessed by performing binding experiments and in vitro release studies, and the obtained results highlighted good selective recognition abilities and sustained release properties. In conclusion, the adopted synthetic strategy involving a lyotropic mesophase system allows for the preparation of effective MIPs characterized by a rod-like morphology. View Full-Text
Keywords: molecularly imprinted polymers; polymeric microrods; mesophase polymerization; theophylline molecularly imprinted polymers; polymeric microrods; mesophase polymerization; theophylline
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Parisi, O.I.; Scrivano, L.; Candamano, S.; Ruffo, M.; Vattimo, A.F.; Spanedda, M.V.; Puoci, F. Molecularly Imprinted Microrods via Mesophase Polymerization. Molecules 2018, 23, 63.

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