Cytotoxic Terpenoids from the Roots of Dracocephalum taliense
AbstractA chemical investigation of methanol extract from the roots of Dracocephalum taliense led to the isolation of a new aromatic abietane diterpenoid, 12-methoxy-18-hydroxy-sugiol (1), and one highly-oxygenated ursane triterpenoid, 2α,3α-dihydroxy-11α,12α-epoxy-urs-28,13β-olide (2), together with 15 known natural products (3–17). Among these, compounds 1–13 and 15–17 were detected for the first time in the genus of Dracocephalum. The structures of all of these isolates were determined by extensively spectroscopic analyses. In the anti-inflammatory assay, compounds 1 and 2 had no obvious inhibitory activity on the release of cytokine IL-2 in lipopolysaccharide-induced RAW 264.7 macrophages. However, compound 2 exhibited significant cytotoxic activity against cell lines HepG2 (IC50 = 6.58 ± 0.14 μM) and NCI-H1975 (IC50 = 7.17 ± 0.26 μM). View Full-Text
- Supplementary File 1:
DOCX-Document (DOCX, 38887 KB)
Share & Cite This Article
Deng, Y.; Hua, J.; Wang, W.; Zhan, Z.; Wang, A.; Luo, S. Cytotoxic Terpenoids from the Roots of Dracocephalum taliense. Molecules 2018, 23, 57.
Deng Y, Hua J, Wang W, Zhan Z, Wang A, Luo S. Cytotoxic Terpenoids from the Roots of Dracocephalum taliense. Molecules. 2018; 23(1):57.Chicago/Turabian Style
Deng, Yanyan; Hua, Juan; Wang, Wenjia; Zhan, Zhonglang; Wang, Anqi; Luo, Shihong. 2018. "Cytotoxic Terpenoids from the Roots of Dracocephalum taliense." Molecules 23, no. 1: 57.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.