Next Article in Journal
DL_ANALYSER Notation for Atomic Interactions (DANAI): A Natural Annotation System for Molecular Interactions, Using Ethanoic Acid Liquid as a Test Case
Next Article in Special Issue
Liposomal TriCurin, A Synergistic Combination of Curcumin, Epicatechin Gallate and Resveratrol, Repolarizes Tumor-Associated Microglia/Macrophages, and Eliminates Glioblastoma (GBM) and GBM Stem Cells
Previous Article in Journal
Molecular Targets for Components of Essential Oils in the Insect Nervous System—A Review
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(1), 38; https://doi.org/10.3390/molecules23010038

Dietary Copper Reduces the Hepatotoxicity of (−)-Epigallocatechin-3-Gallate in Mice

1
Tea Research Institute, Nanjing Agricultural University, Nanjing 210095, China
2
Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 27 November 2017 / Revised: 22 December 2017 / Accepted: 23 December 2017 / Published: 23 December 2017
(This article belongs to the Special Issue Catechin in Human Health and Disease)
Full-Text   |   PDF [2021 KB, uploaded 23 December 2017]   |  

Abstract

We developed Cu-deficient, -sufficient and -super nutrition mice models by feeding them with diet containing 1.68, 11.72 or 51.69 mg of Cu/kg for 28 days, respectively. Then, the mice were treated to (−)-epigallocatechin-3-gallate (EGCG, 750 mg/kg BW) by oral in order to assess the acute toxicity of the drug. Following EGCG treatment, the survival rates were 12.5%, 50% and 100% in the Cu-deficient, -sufficient and Cu-super nutrition groups of mice, respectively. Cu level and ceruloplasmin activity in serum were significantly increased with the increase of dietary Cu. However, the Cu supplementation did not produce any obvious impact on serum superoxide dismutase activity. Furthermore, ceruloplasmin, in vitro, significantly promotes EGCG oxidation accompanied with increasing oxidation products and decreasing levels of reactive oxygen species. These results, therefore, suggest that Cu can relieve EGCG hepatotoxicity, possibly by up-regulating ceruloplasmin activity, which can be used to promote EGCG applications. View Full-Text
Keywords: tea; (−)-epigallocatehin-3-gallate; copper; ceruloplasmin; hepatotoxicity tea; (−)-epigallocatehin-3-gallate; copper; ceruloplasmin; hepatotoxicity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Kaleri, N.A.; Sun, K.; Wang, L.; Li, J.; Zhang, W.; Chen, X.; Li, X. Dietary Copper Reduces the Hepatotoxicity of (−)-Epigallocatechin-3-Gallate in Mice. Molecules 2018, 23, 38.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top