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Molecules 2018, 23(1), 27; doi:10.3390/molecules23010027

Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus

Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan
Faculty of Pharmacy, National Yang-Ming University, Taipei 11221, Taiwan
Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan
Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei 10617, Taiwan
Department of Chemistry, Chung-Yuan Christian University, Chungli 32023, Taiwan
Authors to whom correspondence should be addressed.
Received: 20 November 2017 / Revised: 14 December 2017 / Accepted: 20 December 2017 / Published: 22 December 2017
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Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created. View Full-Text
Keywords: malonamide; Staphylococcus aureus; antibiotics malonamide; Staphylococcus aureus; antibiotics

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Su, J.-C.; Huang, Y.-T.; Chen, C.-S.; Chiu, H.-C.; Shiau, C.-W. Design and Synthesis of Malonamide Derivatives as Antibiotics against Methicillin-Resistant Staphylococcus aureus. Molecules 2018, 23, 27.

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