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Molecules 2018, 23(1), 10; doi:10.3390/molecules23010010

Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000, China
National-Local Joint Engineering Research Center of Entomoceutics, Dali 671000, China
Basic Medical College, Chengde Medical University, Chengde 067000, China
Author to whom correspondence should be addressed.
Received: 17 November 2017 / Revised: 4 December 2017 / Accepted: 6 December 2017 / Published: 21 December 2017
(This article belongs to the Collection Recent Advances in Flavors and Fragrances)
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Blaps rynchopetera Fairmaire has long been used as a folk medicine by the Yi and Bai ethnic groups in China to treat fever, cough, gastritis, boils, and tumors. In the present study, the cytotoxicity of the defensive secretion (TDS) of B. rynchopetera against AGS Caco-2, HepG2 U251 and Bel-7402 was tested, and the results revealed that TDS had potent cytotoxicity against testing cells with IC50 values of 45.8, 17.4, 53.6, 98.4 and 23.4 μg/mL, respectively. Gas chromatography-mass spectrometry (GC-MS) analysis was employed to clarify the cytotoxic constituents in TDS of B. rynchopetera and five volatile compounds, including 2-ethyl-2,5-cyclohexadiene-1,4-dione (3, 31.00%), 1-tridecene (5, 28.02%), 2-methyl-2,5-cyclohexadiene-1,4-dione (2, 22.86%), hydroquinone (4, 1.33%), and p-benzoquinone (1, 1.01%), were identified. Chemical constituent investigation on TDS further supported the presence of 5 above compounds. A cytotoxic assay indicated that compounds 1, 2, 3 and 4 exhibited significant cytotoxicity against the testing cell lines, implying that benzoquinones and hydroquinone played important roles in the cytotoxicity of TDS of B. rynchopetera. TDS is a cytotoxic natural material and further studies investigating mechanisms and inhibitory activities on other cell lines is warranted. View Full-Text
Keywords: Blaps rynchopetera Fairmaire; cytotoxicity; the defensive secretion; benzoquinones; hydroquinone Blaps rynchopetera Fairmaire; cytotoxicity; the defensive secretion; benzoquinones; hydroquinone

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xiao, H.; Dong, J.-W.; Zhou, D.-J.; Wu, X.-M.; Luo, J.-R.; Zhang, C.-G.; Guo, N.-N.; Li, Y.; Cai, L.; Ding, Z.-T. Cytotoxicity of the Defensive Secretion from the Medicinal Insect Blaps rynchopetera. Molecules 2018, 23, 10.

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