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Molecules 2017, 22(9), 1570; doi:10.3390/molecules22091570

Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures

Department of Thoracic, Cardiac and Vascular Surgery, University Hospital Tuebingen, 72076 Tuebingen, Germany
Department of Pharmaceutical Engineering, Albstadt-Sigmaringen University, 72488 Sigmaringen, Germany
Aimecs® GmbH, 84347 Pfarrkirchen, Germany
Section Medical Materials Science & Technology, University Hospital Tuebingen, 72076 Tuebingen, Germany
Author to whom correspondence should be addressed.
Received: 17 August 2017 / Accepted: 16 September 2017 / Published: 19 September 2017
(This article belongs to the Special Issue Biomedical Applications of Polylactide (PLA) and its Copolymers)
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Surgical site infections (SSIs) are one of the most common nosocomial infections, which can result in serious complications after surgical interventions. Foreign materials such as implants or surgical sutures are optimal surfaces for the adherence of bacteria and subsequent colonization and biofilm formation. Due to a significant increase in antibiotic-resistant bacterial strains, naturally occurring agents exhibiting antibacterial properties have great potential in prophylactic therapies. The aim of this study was to develop a coating for surgical sutures consisting of the antibacterial substance totarol, a naturally occurring diterpenoid isolated from Podocarpus totara in combination with poly(lactide-co-glycolide acid) (PLGA) as a biodegradable drug delivery system. Hence, non-absorbable monofilament and multifilament sutures were coated with solutions containing different amounts and ratios of totarol and PLGA, resulting in a smooth, crystalline coating. Using an agar diffusion test (ADT), it became evident that the PLGA/totarol-coated sutures inhibited the growth of Staphylococcus aureus over a period of 15 days. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that the coated sutures were not cytotoxic to murine fibroblasts. Overall, the data indicates that our innovative, biodegradable suture coating has the potential to reduce the risk of SSIs and postoperative biofilm-formation on suture material without adverse effects on tissue. View Full-Text
Keywords: surgical site infection; antibacterial coating; suture; biodegradable; totarol; Staphylococcus aureus surgical site infection; antibacterial coating; suture; biodegradable; totarol; Staphylococcus aureus

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Reinbold, J.; Uhde, A.-K.; Müller, I.; Weindl, T.; Geis-Gerstorfer, J.; Schlensak, C.; Wendel, H.-P.; Krajewski, S. Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures. Molecules 2017, 22, 1570.

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