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Molecules 2017, 22(9), 1570; doi:10.3390/molecules22091570

Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures

1
Department of Thoracic, Cardiac and Vascular Surgery, University Hospital Tuebingen, 72076 Tuebingen, Germany
2
Department of Pharmaceutical Engineering, Albstadt-Sigmaringen University, 72488 Sigmaringen, Germany
3
Aimecs® GmbH, 84347 Pfarrkirchen, Germany
4
Section Medical Materials Science & Technology, University Hospital Tuebingen, 72076 Tuebingen, Germany
*
Author to whom correspondence should be addressed.
Received: 17 August 2017 / Accepted: 16 September 2017 / Published: 19 September 2017
(This article belongs to the Special Issue Biomedical Applications of Polylactide (PLA) and its Copolymers)
View Full-Text   |   Download PDF [3564 KB, uploaded 19 September 2017]   |  

Abstract

Surgical site infections (SSIs) are one of the most common nosocomial infections, which can result in serious complications after surgical interventions. Foreign materials such as implants or surgical sutures are optimal surfaces for the adherence of bacteria and subsequent colonization and biofilm formation. Due to a significant increase in antibiotic-resistant bacterial strains, naturally occurring agents exhibiting antibacterial properties have great potential in prophylactic therapies. The aim of this study was to develop a coating for surgical sutures consisting of the antibacterial substance totarol, a naturally occurring diterpenoid isolated from Podocarpus totara in combination with poly(lactide-co-glycolide acid) (PLGA) as a biodegradable drug delivery system. Hence, non-absorbable monofilament and multifilament sutures were coated with solutions containing different amounts and ratios of totarol and PLGA, resulting in a smooth, crystalline coating. Using an agar diffusion test (ADT), it became evident that the PLGA/totarol-coated sutures inhibited the growth of Staphylococcus aureus over a period of 15 days. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that the coated sutures were not cytotoxic to murine fibroblasts. Overall, the data indicates that our innovative, biodegradable suture coating has the potential to reduce the risk of SSIs and postoperative biofilm-formation on suture material without adverse effects on tissue. View Full-Text
Keywords: surgical site infection; antibacterial coating; suture; biodegradable; totarol; Staphylococcus aureus surgical site infection; antibacterial coating; suture; biodegradable; totarol; Staphylococcus aureus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Reinbold, J.; Uhde, A.-K.; Müller, I.; Weindl, T.; Geis-Gerstorfer, J.; Schlensak, C.; Wendel, H.-P.; Krajewski, S. Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures. Molecules 2017, 22, 1570.

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