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Molecules 2017, 22(9), 1547; doi:10.3390/molecules22091547

Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818

1
Shandong Provincial Key Laboratory of Synthetic Biology, CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Qingdao 266101, China
2
Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304, USA
3
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
*
Authors to whom correspondence should be addressed.
Received: 9 August 2017 / Revised: 22 August 2017 / Accepted: 11 September 2017 / Published: 14 September 2017
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Abstract

Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β-unsaturated δ-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (5′-adenosine monophosphate-activated protein kinase). View Full-Text
Keywords: polyketide; mycoepoxydiene; cyclooctadiene; endophtic fungus; cytotoxicity polyketide; mycoepoxydiene; cyclooctadiene; endophtic fungus; cytotoxicity
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Zhang, W.; Zhao, B.; Du, L.; Shen, Y. Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818. Molecules 2017, 22, 1547.

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