Next Article in Journal
Visible Light-Cured Glycol Chitosan Hydrogel Containing a Beta-Cyclodextrin-Curcumin Inclusion Complex Improves Wound Healing In Vivo
Next Article in Special Issue
Promoting Effect of Pinostrobin on the Proliferation, Differentiation, and Mineralization of Murine Pre-osteoblastic MC3T3-E1 Cells
Previous Article in Journal
The Application of Quantitative 1H-NMR for the Determination of Orlistat in Tablets
Previous Article in Special Issue
Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(9), 1515; doi:10.3390/molecules22091515

Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine

1
Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA
2
College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Korea
3
College of Pharmacy, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongbuk 38430, Korea
4
School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Korea
5
Department of Rehabilitation Medicine, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea
Tae Hwan Kim and Soyoung Shin contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 10 July 2017 / Revised: 1 September 2017 / Accepted: 8 September 2017 / Published: 10 September 2017
View Full-Text   |   Download PDF [1319 KB, uploaded 10 September 2017]   |  

Abstract

Gemcitabine and erlotinib are the chemotherapeutic agents used in the treatment of various cancers and their combination is being accepted as a first-line treatment of advanced pancreatic cancer. Hyangsayukgunja-tang (HYT) is a traditional oriental medicine used in various digestive disorders and potentially helpful to treat gastrointestinal adverse effects related to chemotherapy. The present study was aimed to evaluate the effect of HYT on the pharmacokinetics of gemcitabine and erlotinib given simultaneously in rats. Rats were pretreated with HYT at an oral dose of 1200 mg/kg/day once daily for a single day or 14 consecutive days. Immediately after pretreatment with HYT, gemcitabine and erlotinib were administered by intravenous injection (10 mg/kg) and oral administration (20 mg/kg), respectively. The effects of HYT on pharmacokinetics of the two drugs were estimated by non-compartmental analysis and pharmacokinetic modeling. The pharmacokinetics of gemcitabine and erlotinib were not altered by single dose HYT pretreatment. However, the plasma levels of OSI-420 and OSI-413, active metabolites of erlotinib, were significantly decreased in the multiple dose HYT pretreatment group. The pharmacokinetic model estimated increased systemic clearances of OSI-420 and OSI-413 by multiple doses of HYT. These data suggest that HYT may affect the elimination of OSI-420 and OSI-413. View Full-Text
Keywords: herbal medicine; drug-drug interaction; pharmacokinetics; gemcitabine; erlotinib; Hyangsayukgunja-tang; population pharmacokinetic modeling herbal medicine; drug-drug interaction; pharmacokinetics; gemcitabine; erlotinib; Hyangsayukgunja-tang; population pharmacokinetic modeling
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kim, T.H.; Shin, S.; Kim, S.; Bulitta, J.B.; Weon, K.-Y.; Joo, S.H.; Ma, E.; Yoo, S.D.; Park, G.-Y.; Kwon, D.R.; Jeong, S.W.; Lee, D.Y.; Shin, B.S. Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine. Molecules 2017, 22, 1515.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top