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Molecules 2017, 22(9), 1452; doi:10.3390/molecules22091452

Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2

1
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China
2
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong 999077, Hong Kong, China
*
Authors to whom correspondence should be addressed.
Received: 25 July 2017 / Accepted: 30 August 2017 / Published: 1 September 2017
(This article belongs to the Section Natural Products)
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Abstract

As a folk medicinal plant, Juglans mandshurica has been used for the treatment of cancer in China and Korea. Traditionally, J. mandshurica is decocted together with chicken eggs. Both the decoction and medicated eggs possess anti-tumor properties. Clarifying the constituents of the decoction and absorbed by the medicated eggs is essential for the investigation of the active principles of J. mandshurica. Herein, the medicated eggs were prepared by decocting raw chicken eggs, having unbroken shells, with the decoction of J. mandshurica. A systematic investigation of the chemical profile of the J. mandshurica decoction and the medicated egg extraction was conducted by HPLC-Q-TOF-MS2. In total, 93 peaks, including 45 tannins, 14 naphthalene derivatives, 17 organic acids, 3 diarylheptanoids, 4 lignans, 3 anthraquinones, 1 flavonoid glycoside, 3 amino acids, and 3 nitrogenous compounds, were tentatively identified in the decoction. In the medicated egg extraction, 44 peaks including 11 organic acids, 3 amino acids, 3 nitrogenous compounds, 8 naphthalene derivatives, 3 diarylheptanoids, 15 tannins, and 1 lignan were tentatively identified. The chemical profile presented provided a detailed overview of the polar chemical constituents in J. mandshurica and useful information for the research of bioactive compounds of this plant. View Full-Text
Keywords: Juglans mandshurica; constituents; decoction; absorption; medicated eggs; HPLC-Q-TOF-MS2 Juglans mandshurica; constituents; decoction; absorption; medicated eggs; HPLC-Q-TOF-MS2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, T.-M.; Fu, Y.; Yu, W.-J.; Chen, C.; Di, X.; Zhang, H.; Zhai, Y.-J.; Chu, Z.-Y.; Kang, T.-G.; Chen, H.-B. Identification of Polar Constituents in the Decoction of Juglans mandshurica and in the Medicated Egg Prepared with the Decoction by HPLC-Q-TOF MS2. Molecules 2017, 22, 1452.

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