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Molecules 2017, 22(9), 1413; doi:10.3390/molecules22091413

Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities

1,2,†
,
3,†,* , 1,* , 1
,
4
and
1
1
Key Laboratory of Biotechnology and Bioresources Utilization, Educational of Minister, College of Life Science, Dalian Nationalities University, Dalian 116600, China
2
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3
Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China
4
Department of Pharmacognosy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 4 August 2017 / Accepted: 14 August 2017 / Published: 25 August 2017
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Abstract

Two new dihydrochalcone enantiomers (+)-1 and (−)-1, along with eight known compounds 310, were obtained from Pteris ensiformis. The planar structures were determined on the basis of extensive 1D and 2DNMR and HRESIMS. The resolution of (+)-1 and (−)-1 was achieved by chiral HPLC analysis. The absolute configurations of (+)-1 and (−)-1 were established by the bulkiness rule using Rh2(O2CCF3)4-induced circular dichroism (ICD) method. Compounds (+)-1, (−)-1, 8, 9 and 10 exhibited the inhibitory assay of NO production in mouse macrophages stimulated by LPS, with IC50 values of 2.0, 2.5, 8.0, 9.5 and 5.6 μM, respectively. Otherwise, compound 10 showed moderate cytotoxic activity against HCT-116, HepG-2 and BGC-823 cell lines with IC50 values of 3.0, 10.5 and 6.3 μM, respectively. View Full-Text
Keywords: Pteris ensiformis; dihydrochalcone; diterpenoid; inhibitory activity on nitric oxide production; cytotoxic activity Pteris ensiformis; dihydrochalcone; diterpenoid; inhibitory activity on nitric oxide production; cytotoxic activity
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MDPI and ACS Style

Shi, Y.-S.; Zhang, Y.; Hu, W.-Z.; Zhang, X.-F.; Fu, X.; Lv, X. Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities. Molecules 2017, 22, 1413.

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