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Molecules 2017, 22(9), 1408; doi:10.3390/molecules22091408

Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity

School of Health Sciences, Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 15784 Athens, Greece
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Received: 7 August 2017 / Revised: 22 August 2017 / Accepted: 23 August 2017 / Published: 25 August 2017
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Abstract

Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have been developed as molecular probes in oncology. Moreover, various σR ligands generate cancer cell death in vitro and in vivo. These σR ligands have exhibited promising results against numerous human and rodent cancers and are investigated under preclinical and clinical study trials, indicating a new category of drugs in cancer therapy. View Full-Text
Keywords: sigma 1 receptor antagonist; sigma 2 receptor agonist; antiproliferative activity; anticancer activity; radiolabeled and fluorescent probes; biomarkers sigma 1 receptor antagonist; sigma 2 receptor agonist; antiproliferative activity; anticancer activity; radiolabeled and fluorescent probes; biomarkers
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Georgiadis, M.-O.; Karoutzou, O.; Foscolos, A.-S.; Papanastasiou, I. Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity. Molecules 2017, 22, 1408.

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