Next Article in Journal
Preclinical Assessment of a 68Ga-DOTA-Functionalized Depsipeptide as a Radiodiagnostic Infection Imaging Agent
Next Article in Special Issue
Halogen Bonds Formed between Substituted Imidazoliums and N Bases of Varying N-Hybridization
Previous Article in Journal
Phytochemistry, Pharmacology and Traditional Uses of Plants from the Genus Trachelospermum L.
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessFeature PaperReview
Molecules 2017, 22(9), 1397; doi:10.3390/molecules22091397

Looking Back, Looking Forward at Halogen Bonding in Drug Discovery

1
Department of Chemistry, The University of Texas at El Paso, El Paso, TX 79968, USA
2
Environmental Science and Engineering Program, The University of Texas at El Paso, El Paso, TX 79968, USA
3
School of Pharmacy, The University of Texas at El Paso, El Paso, TX 79968, USA
*
Author to whom correspondence should be addressed.
Received: 7 July 2017 / Accepted: 18 August 2017 / Published: 24 August 2017
(This article belongs to the Special Issue Halogen Bonds and Beyond)
View Full-Text   |   Download PDF [2629 KB, uploaded 24 August 2017]   |  

Abstract

Halogen bonding has emerged at the forefront of advances in improving ligand: receptor interactions. In particular the newfound ability of this extant non-covalent-bonding phenomena has revolutionized computational approaches to drug discovery while simultaneously reenergizing synthetic approaches to the field. Here we survey, via examples of classical applications involving halogen atoms in pharmaceutical compounds and their biological hosts, the unique advantages that halogen atoms offer as both Lewis acids and Lewis bases. View Full-Text
Keywords: halogen bonding; sigma-hole; Lewis base; Lewis acid; drug discovery halogen bonding; sigma-hole; Lewis base; Lewis acid; drug discovery
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mendez, L.; Henriquez, G.; Sirimulla, S.; Narayan, M. Looking Back, Looking Forward at Halogen Bonding in Drug Discovery. Molecules 2017, 22, 1397.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top