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Molecules 2017, 22(8), 1346; doi:10.3390/molecules22081346

ADP-ribosyl-N3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds

Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering Henan Normal University, Xinxiang 453007, Henan, China
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Received: 29 June 2017 / Revised: 11 August 2017 / Accepted: 11 August 2017 / Published: 14 August 2017
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Abstract

Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology tools and discover new drug candidates. However, the synthesis of ADP-ribosylated compounds is currently difficult due to structural complexity, easily broken pyrophosphate bond and high hydrophilicity. In this paper, ADP-ribosyl-N3 was designed and synthesized for the first time. With ADP-ribosyl-N3 as the key precursor, a divergent post-modification strategy was developed to prepare structurally diverse ADP-ribosylated compounds including novel nucleotides and peptides bearing ADP-ribosyl moieties. View Full-Text
Keywords: nucleotides; ADP-ribosylated compounds; divergent synthesis nucleotides; ADP-ribosylated compounds; divergent synthesis
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Li, L.; Li, Q.; Ding, S.; Xin, P.; Zhang, Y.; Huang, S.; Zhang, G. ADP-ribosyl-N3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds. Molecules 2017, 22, 1346.

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