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Molecules 2017, 22(8), 1334; doi:10.3390/molecules22081334

H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation

1
,
2,3,4
,
2,5
,
2,3,4
and
1,2,6,*
1
School of Kinesiology, Lakehead University, Thunder Bay, ON P7B 5E1, Canada
2
Cardiovascular and Metabolic Research Unit, Laurentian University, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada
3
School of Human Kinetics, Laurentian University, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada
4
Health Science North Research Institute, 41 Ramsey Lake Rd, Sudbury, ON P3E 5J1, Canada
5
The Department of Biology, Laurentian University, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada
6
The Department of Chemistry and Biochemistry, Laurentian University, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada
*
Author to whom correspondence should be addressed.
Received: 16 June 2017 / Revised: 26 July 2017 / Accepted: 4 August 2017 / Published: 11 August 2017
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1816 KB, uploaded 11 August 2017]   |  

Abstract

Protein S-sulfhydration is a newly discovered post-translational modification of specific cysteine residue(s) in target proteins, which is involved in a broad range of cellular functions and metabolic pathways. By changing local conformation and the final activity of target proteins, S-sulfhydration is believed to mediate most cellular responses initiated by H2S, a novel gasotransmitter. In comparison to protein S-sulfhydration, nitric oxide-mediated protein S-nitrosylation has been extensively investigated, including its formation, regulation, transfer and metabolism. Although the investigation on the regulatory mechanisms associated with protein S-sulfhydration is still in its infancy, accumulated evidence suggested that protein S-sulfhydration may share similar chemical features with protein S-nitrosylation. Glutathione persulfide acts as a major donor for protein S-sulfhydration. Here, we review the present knowledge on protein S-sulfhydration, and also predict its formation and regulation mechanisms based on the knowledge from protein S-nitrosylation. View Full-Text
Keywords: hydrogen sulfide; nitric oxide; cysteine; S-sulfhydration; S-nitrosylation hydrogen sulfide; nitric oxide; cysteine; S-sulfhydration; S-nitrosylation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ju, Y.; Fu, M.; Stokes, E.; Wu, L.; Yang, G. H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation. Molecules 2017, 22, 1334.

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