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Molecules 2017, 22(8), 1319; doi:10.3390/molecules22081319

Cytotoxic and Antiviral Triterpenoids from the Mangrove Plant Sonneratia paracaseolaris

1
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
College of Chemistry and Chemical Engineering, Ocean University of China, Songling Road 238, Qingdao 266100, China
3
Cancer Research institute, Binzhou Medical University Hospital, Yellow river second Road 661, Binzhou 256603, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 18 July 2017 / Revised: 2 August 2017 / Accepted: 7 August 2017 / Published: 9 August 2017
(This article belongs to the Section Natural Products)
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Abstract

A chemical investigation was conducted on the aerial parts of the mangrove plant Sonneratia paracaseolaris, yielding five new triterpenoid paracaseolins A–E (14, and 11) together with twelve known analogues (510, 1217). Their structures were established by extensive spectroscopic methods and comparisons their spectroscopic data with those of the known related compounds. The cytotoxicities against P388, HeLa, A549, and K562 tumor cell lines and anti-H1N1 (Influenza A virus) activities for the isolates were evaluated. Compound 4 showed potent cytotoxicity against the A549 cell line with an IC50 value of 1.89 µM, and compound 1 exhibited significant anti-H1N1 virus activity with an IC50 value of 28.4 µg/mL. A preliminary structure activity relationship was discussed. View Full-Text
Keywords: mangrove plant; Sonneratia paracaseolaris; triterpenoids; cytotoxicities; anti-H1N1 activities mangrove plant; Sonneratia paracaseolaris; triterpenoids; cytotoxicities; anti-H1N1 activities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gong, K.-K.; Li, P.-L.; Qiao, D.; Zhang, X.-W.; Chu, M.-J.; Qin, G.-F.; Tang, X.-L.; Li, G.-Q. Cytotoxic and Antiviral Triterpenoids from the Mangrove Plant Sonneratia paracaseolaris. Molecules 2017, 22, 1319.

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