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Molecules 2017, 22(8), 1301; doi:10.3390/molecules22081301

Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000, China
Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai 519041, China
Author to whom correspondence should be addressed.
Received: 9 July 2017 / Accepted: 31 July 2017 / Published: 4 August 2017
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Five new phenolic compounds rynchopeterines A–E (15), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (14) exhibited significant antioxidant activities with IC50 values of 7.67–12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549. View Full-Text
Keywords: Blaps rynchopetera; chemical constituents; phenolic; rynchopeterines A–E; antioxidant; anti-tumor Blaps rynchopetera; chemical constituents; phenolic; rynchopeterines A–E; antioxidant; anti-tumor

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Xiao, H.; Yin, T.-P.; Dong, J.-W.; Wu, X.-M.; Luo, Q.; Luo, J.-R.; Cai, L.; Ding, Z.-T. Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera. Molecules 2017, 22, 1301.

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