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Molecules 2017, 22(8), 1301; doi:10.3390/molecules22081301

Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera

1
Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
2
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000, China
3
Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai 519041, China
*
Author to whom correspondence should be addressed.
Received: 9 July 2017 / Accepted: 31 July 2017 / Published: 4 August 2017
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Abstract

Five new phenolic compounds rynchopeterines A–E (15), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (14) exhibited significant antioxidant activities with IC50 values of 7.67–12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549. View Full-Text
Keywords: Blaps rynchopetera; chemical constituents; phenolic; rynchopeterines A–E; antioxidant; anti-tumor Blaps rynchopetera; chemical constituents; phenolic; rynchopeterines A–E; antioxidant; anti-tumor
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Xiao, H.; Yin, T.-P.; Dong, J.-W.; Wu, X.-M.; Luo, Q.; Luo, J.-R.; Cai, L.; Ding, Z.-T. Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera. Molecules 2017, 22, 1301.

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