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Molecules 2017, 22(8), 1277; doi:10.3390/molecules22081277

An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base

1
College of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, Jiangxi, China
2
Engineering Center of Jiangxi University for Lithium Energy, Yichun University, Yichun 336000, Jiangxi, China
*
Author to whom correspondence should be addressed.
Received: 29 June 2017 / Revised: 20 July 2017 / Accepted: 29 July 2017 / Published: 31 July 2017
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Abstract

An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-dimethylformamide (DMF) under air at 140 °C with K2CO3 as catalyst. View Full-Text
Keywords: arylated pyridines; synthesis; transition-metal-free; base; catalysis arylated pyridines; synthesis; transition-metal-free; base; catalysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guo, M.; Chen, B.; Zhu, Q.; Jin, H.; Peng, Q.; Kang, Y. An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base. Molecules 2017, 22, 1277.

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