Next Article in Journal
Kinetics and Energetics of Thermal Cis-Trans Isomerization of a Resonance-Activated Azobenzene in BMIM-Based Ionic Liquids for PF6/Tf2N Comparison
Next Article in Special Issue
Novel Methylselenoesters as Antiproliferative Agents
Previous Article in Journal
β-Formyl- and β-Vinylporphyrins: Magic Building Blocks for Novel Porphyrin Derivatives
Previous Article in Special Issue
Newly Synthesized Doxorubicin Complexes with Selected Metals—Synthesis, Structure and Anti-Breast Cancer Activity
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Molecules 2017, 22(8), 1270; doi:10.3390/molecules22081270

Research Progress in the Modification of Quercetin Leading to Anticancer Agents

1
Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Ferrara, Via Luigi Borsari 46, I-44121 Ferrara, Italy
2
Dipartimento di Scienze della Vita e Biotecnologie, Sezione di Botanica Applicata, Piazzale Luciano Chiappini 3, I-44123 Ferrara, Italy
*
Author to whom correspondence should be addressed.
Received: 26 June 2017 / Revised: 24 July 2017 / Accepted: 25 July 2017 / Published: 29 July 2017
View Full-Text   |   Download PDF [5215 KB, uploaded 29 July 2017]   |  

Abstract

The flavonoid quercetin (3,3′,4′,5,7-pentahydroxyflavone) is widely distributed in plants, foods, and beverages. This polyphenol compound exhibits varied biological actions such as antioxidant, radical-scavenging, anti-inflammatory, antibacterial, antiviral, gastroprotective, immune-modulator, and finds also application in the treatment of obesity, cardiovascular diseases and diabetes. Besides, quercetin can prevent neurological disorders and exerts protection against mitochondrial damages. Various in vitro studies have assessed the anticancer effects of quercetin, although there are no conclusive data regarding its mode of action. However, low bioavailability, poor aqueous solubility as well as rapid body clearance, fast metabolism and enzymatic degradation hamper the use of quercetin as therapeutic agent, so intense research efforts have been focused on the modification of the quercetin scaffold to obtain analogs with potentially improved properties for clinical applications. This review gives an overview of the developments in the synthesis and anticancer-related activities of quercetin derivatives reported from 2012 to 2016. View Full-Text
Keywords: quercetin; quercetin derivatives; methoxyflavones; anticancer; cell proliferation; cytotoxicity; multi-drug resistance (MDR) quercetin; quercetin derivatives; methoxyflavones; anticancer; cell proliferation; cytotoxicity; multi-drug resistance (MDR)
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Massi, A.; Bortolini, O.; Ragno, D.; Bernardi, T.; Sacchetti, G.; Tacchini, M.; De Risi, C. Research Progress in the Modification of Quercetin Leading to Anticancer Agents. Molecules 2017, 22, 1270.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top