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Molecules 2017, 22(7), 1218; doi:10.3390/molecules22071218

Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice

1
Lab of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
2
Hong Kong Baptist University Shenzhen Research Institute and Continuing Education, 518057 Shenzhen, China
3
Preparatory Office of Shenzhen-Melbourne Institute of Life Sciences and Bioengineering, Guangzhou University of Chinese Medicine, 510006 Guangzhou, China
4
YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, 650500 Kunming, China
*
Authors to whom correspondence should be addressed.
Received: 30 June 2017 / Revised: 18 July 2017 / Accepted: 18 July 2017 / Published: 20 July 2017
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Abstract

Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7 days. The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity. Moreover, colonic pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) induced by colitis were dramatically decreased by magnolol. To further unveil the metabolic signatures upon magnolol treatment, mass spectrometry-based metabolomic analysis of the small molecular metabolites in mice serum were performed. Compared with controls, abnormality of serum metabolic phenotypes in DSS-treated mice were effectively reversed by different doses of magnolol. In particular, magnolol treatment effectively elevated the serum levels of tryptophan metabolites including kynurenic acid (KA), 5-hydroxyindoleacetic acid, indoleacetic acid (IAA), indolelactic acid and indoxylsulfuric acid, which are potential aryl hydrocarbon receptor (AHR) ligands to impact colitis. These findings suggest that magnolol exerts anti-inflammatory effect on DSS-induced colitis and its underlying mechanisms are associated with the restoring of tryptophan metabolites that inhibit the colonic inflammation. View Full-Text
Keywords: magnolol; inflammation; ulcerative colitis; tryptophan metabolites magnolol; inflammation; ulcerative colitis; tryptophan metabolites
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Zhao, L.; Xiao, H.-T.; Mu, H.-X.; Huang, T.; Lin, Z.-S.; Zhong, L.L.D.; Zeng, G.-Z.; Fan, B.-M.; Lin, C.-Y.; Bian, Z.-X. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules 2017, 22, 1218.

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