Next Article in Journal
Immunomodulatory Activity of Octenyl Succinic Anhydride Modified Porang (Amorphophallus oncophyllus) Glucomannan on Mouse Macrophage-Like J774.1 Cells and Mouse Primary Peritoneal Macrophages
Next Article in Special Issue
Role of G Protein-Coupled Receptors in the Regulation of Structural Plasticity and Cognitive Function
Previous Article in Journal
Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length
Previous Article in Special Issue
c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Molecules 2017, 22(7), 1188; doi:10.3390/molecules22071188

Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors

1
Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modelling Lab, Medical University of Lublin, 4A Chodźki Str., Lublin PL20093, Poland
2
School of Pharmacy, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, Kuopio FI-70211, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Yung Hou Wong
Received: 13 April 2017 / Revised: 4 July 2017 / Accepted: 10 July 2017 / Published: 15 July 2017
(This article belongs to the Special Issue G-protein Coupled Receptor Structure and Function)
View Full-Text   |   Download PDF [2569 KB, uploaded 15 July 2017]   |  

Abstract

In recent years, our understanding of function of G protein-coupled receptors (GPCRs) has changed from a picture of simple signal relays, transmitting only a particular signal to a particular G protein heterotrimer, to versatile machines, capable of various responses to different stimuli and being modulated by various factors. Some recent reports provide not only the data on ligands/modulators and resultant signals induced by them, but also deeper insights into exact pathways of signal migration and mechanisms of signal transmission through receptor structure. Combination of these computational and experimental data sheds more light on underlying mechanisms of signal transmission and signaling bias in GPCRs. In this review we focus on available clues on allosteric pathways responsible for complex signal processing within GPCRs structures, with particular emphasis on linking compatible in silico- and in vitro-derived data on the most probable allosteric connections. View Full-Text
Keywords: GPCRs; signaling; allostery; protein dynamics GPCRs; signaling; allostery; protein dynamics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bartuzi, D.; Kaczor, A.A.; Matosiuk, D. Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors. Molecules 2017, 22, 1188.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top