Next Article in Journal
The [Mo6Cl14]2− Cluster is Biologically Secure and Has Anti-Rotavirus Activity In Vitro
Next Article in Special Issue
Antioxidant Capacity, Anticancer Ability and Flavonoids Composition of 35 Citrus (Citrus reticulata Blanco) Varieties
Previous Article in Journal
Newly Synthesized Doxorubicin Complexes with Selected Metals—Synthesis, Structure and Anti-Breast Cancer Activity
Previous Article in Special Issue
Antibacterial Activities of Pyrenylated Coumarins from the Roots of Prangos hulusii
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Molecules 2017, 22(7), 1100; doi:10.3390/molecules22071100

Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves

1
Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia 74605-050, Brazil
2
Unit of Exact and Technologic Sciences, Goias State University, Anápolis 75132-400, Brazil
3
Faculty of Pharmacy, Federal University of Goias, Goiânia 74605-170, Brazil
4
Chemistry Institute, Federal University of Goiás, Goiânia 74690-900, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 23 May 2017 / Accepted: 29 June 2017 / Published: 4 July 2017
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [449 KB, uploaded 8 July 2017]   |  

Abstract

This work describes the isolation and structural elucidation of compounds from the leaves of Myrcia tomentosa (Aubl.) DC. (goiaba-brava) and evaluates the antimicrobial activity of the crude extract, fractions and isolated compounds against bacteria and fungi. Column chromatography was used to fractionate and purify the extract of the M. tomentosa leaves and the chemical structures of the compounds were determined using spectroscopic techniques. The antibacterial and antifungal activities were assessed using the broth microdilution method. The phytochemical investigation isolated 11 compounds: α-bisabolol, α-bisabolol oxide B, α-cadinol, β-sitosterol, n-pentacosane, n-tetracosane, quercetin, kaempferol, avicularin, juglanin and guaijaverin. The crude ethanolic extract and its fractions were tested against 15 bacteria and 9 yeasts. The crude extract inhibited the in vitro growth of yeasts at concentration of 4 to 32 μg/mL. The hexane, dichloromethane, ethyl acetate and aqueous fractions inhibited Candida sp. at concentrations of 4 to 256 μg/mL, whereas the Cryptococcus sp. isolates were inhibited only by the hexane and dichloromethane fractions in minimal inhibitory concentrations (MICs) at 16 to 64 μg/mL. The flavonoid quercetin-3-O-α-arabinofuranose (avicularin) was the most active compound, inhibiting Candida species in concentrations of 2 to 32 μg/mL. The MIC values suggest potential activity of this plant species against yeast. View Full-Text
Keywords: myrtaceae; antifungal activity; avicularin; Candida sp.; phytochemistry; flavonoid myrtaceae; antifungal activity; avicularin; Candida sp.; phytochemistry; flavonoid
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

da Silva Sa, F.A.; de Paula, J.A.M.; dos Santos, P.A.; de Almeida Ribeiro Oliveira, L.; de Almeida Ribeiro Oliveira, G.; Liao, L.M.; de Paula, J.R.; do Rosario Rodrigues Silva, M. Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves. Molecules 2017, 22, 1100.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top