Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves
AbstractThis work describes the isolation and structural elucidation of compounds from the leaves of Myrcia tomentosa (Aubl.) DC. (goiaba-brava) and evaluates the antimicrobial activity of the crude extract, fractions and isolated compounds against bacteria and fungi. Column chromatography was used to fractionate and purify the extract of the M. tomentosa leaves and the chemical structures of the compounds were determined using spectroscopic techniques. The antibacterial and antifungal activities were assessed using the broth microdilution method. The phytochemical investigation isolated 11 compounds: α-bisabolol, α-bisabolol oxide B, α-cadinol, β-sitosterol, n-pentacosane, n-tetracosane, quercetin, kaempferol, avicularin, juglanin and guaijaverin. The crude ethanolic extract and its fractions were tested against 15 bacteria and 9 yeasts. The crude extract inhibited the in vitro growth of yeasts at concentration of 4 to 32 μg/mL. The hexane, dichloromethane, ethyl acetate and aqueous fractions inhibited Candida sp. at concentrations of 4 to 256 μg/mL, whereas the Cryptococcus sp. isolates were inhibited only by the hexane and dichloromethane fractions in minimal inhibitory concentrations (MICs) at 16 to 64 μg/mL. The flavonoid quercetin-3-O-α-arabinofuranose (avicularin) was the most active compound, inhibiting Candida species in concentrations of 2 to 32 μg/mL. The MIC values suggest potential activity of this plant species against yeast. View Full-Text
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da Silva Sa, F.A.; de Paula, J.A.M.; dos Santos, P.A.; de Almeida Ribeiro Oliveira, L.; de Almeida Ribeiro Oliveira, G.; Liao, L.M.; de Paula, J.R.; do Rosario Rodrigues Silva, M. Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves. Molecules 2017, 22, 1100.
da Silva Sa FA, de Paula JAM, dos Santos PA, de Almeida Ribeiro Oliveira L, de Almeida Ribeiro Oliveira G, Liao LM, de Paula JR, do Rosario Rodrigues Silva M. Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves. Molecules. 2017; 22(7):1100.Chicago/Turabian Style
da Silva Sa, Fabyola A.; de Paula, Joelma A.M.; dos Santos, Pierre A.; de Almeida Ribeiro Oliveira, Leandra; de Almeida Ribeiro Oliveira, Gerlon; Liao, Luciano M.; de Paula, Jose R.; do Rosario Rodrigues Silva, Maria. 2017. "Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves." Molecules 22, no. 7: 1100.
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