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Molecules 2017, 22(7), 1085; doi:10.3390/molecules22071085

An All-Nanocrystal Biosensing System for In Vitro Detection of STAT3 Oligonucleotides

1,2
,
1
and
1,2,*
1
Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong, China
2
City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, China
*
Author to whom correspondence should be addressed.
Received: 19 May 2017 / Revised: 26 June 2017 / Accepted: 27 June 2017 / Published: 29 June 2017
(This article belongs to the Special Issue Nanocrystals: Synthesis, Characterization and Applications)
View Full-Text   |   Download PDF [7675 KB, uploaded 29 June 2017]   |  

Abstract

Lanthanide-doped nanocrystals have shown great promise in bio-detection due to their outstanding luminescent properties, including large Stokes shift and sharp emission bands. Herein, we describe an in vitro detection of STAT3 by using an all-nanocrystal biosensing system that takes advantage of inter-particle energy transfer between two types of lanthanide-doped nanocrystals. We investigate the effect of nanocrystal size on the sensing performance and find that smaller nanocrystals offer a lower detection limit and larger dynamic range. As STAT3 is identified as an oncogene aberrantly activated and expressed in malignant transformation and tumorigenesis, our study thus holds promise for cancer diagnosis and therapy. View Full-Text
Keywords: lanthanide; nanocrystals; photoluminescence; energy migration; STAT3; DNA sensing lanthanide; nanocrystals; photoluminescence; energy migration; STAT3; DNA sensing
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Kong, W.; Lam, C.F.; Wang, F. An All-Nanocrystal Biosensing System for In Vitro Detection of STAT3 Oligonucleotides. Molecules 2017, 22, 1085.

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