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Molecules 2017, 22(7), 1071; doi:10.3390/molecules22071071

In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants

1
GNOS Research Group, Louvain Drug Research Institue, Université Catholique de Louvain, Bruxelles 1200, Belgium
2
Department of Pharmacognosy, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi 100000, Vietnam
3
Department of Botany, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi 100000, Vietnam
4
TFAR Research Group, Louvain Drug Research Institue, Université Catholique de Louvain, Bruxelles 1200, Belgium
*
Authors to whom correspondence should be addressed.
Received: 4 May 2017 / Revised: 21 June 2017 / Accepted: 22 June 2017 / Published: 27 June 2017
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
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Abstract

Leishmania mexicana is one of the pathogens causing cutaneous leishmaniasis which is associated with patient morbidity. In our researches for new safe and effective treatments, thirty-seven essential oils (EOs) extracted from Vietnamese plants were screened in vitro for the first time on Leishmania mexicana mexicana (Lmm) promastigotes at the maximum concentration of 50 nL/mL. Active EOs were also analyzed for cytotoxicity on mammalian cell lines (WI38, J774) and their selectivity indices (SI) were calculated. Their composition was determined by GC-MS and GC-FID. Our results indicated that EOs extracted from Cinnamomum cassia, Zingiber zerumbet, Elsholtzia ciliata and Amomum aromaticum, possessed a moderate anti-leishmanial activity, with IC50 values of 2.92 ± 0.08, 3.34 ± 0.34, 8.49 ± 0.32 and 9.25 ± 0.64 nL/mL respectively. However, they also showed cytotoxicity with SI < 10. The most promising EO was extracted from Ocimum gratissimum, displaying an IC50 of 4.85 ± 1.65 nL/mL and SI > 10. It contained 86.5% eugenol, which was demonstrated to be effective on Lmm with IC50 of 2.57 ± 0.57 nL/mL and not toxic on mammalian cells, explaining the observed activity. View Full-Text
Keywords: Leishmania mexicana mexicana; essential oils; Ocimum gratissimum; Cinnamomum cassia; Zingiber zerumbet; Elsholtzia ciliata; Amomum aromaticum; eugenol Leishmania mexicana mexicana; essential oils; Ocimum gratissimum; Cinnamomum cassia; Zingiber zerumbet; Elsholtzia ciliata; Amomum aromaticum; eugenol
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Le, T.B.; Beaufay, C.; Nghiem, D.T.; Mingeot-Leclercq, M.-P.; Quetin-Leclercq, J. In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants. Molecules 2017, 22, 1071.

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