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Molecules 2017, 22(7), 1069; doi:10.3390/molecules22071069

Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis

College of Pharmacy, Pusan National University, Busan 46241, Korea
College of Pharmacy, Institute of Pharmaceutical Sciences, Cha University, Pocheon-si 11160, Korea
College of Pharmacy, Dankook University, Cheonan 31116, Korea
College of Pharmacy, Kyungsung University, Busan 48434, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 28 May 2017 / Accepted: 21 June 2017 / Published: 26 June 2017
(This article belongs to the Special Issue Asymmetric Synthesis 2017)


Asymmetric synthesis of naturally occurring diverse ring systems is an ongoing and challenging research topic. A large variety of remarkable reactions utilizing chiral substrates, auxiliaries, reagents, and catalysts have been intensively investigated. This review specifically describes recent advances in successful asymmetric cyclization reactions to generate cyclic architectures of various natural products in a substrate-controlled manner. View Full-Text
Keywords: asymmetric cyclization; substrate-controlled manner; total synthesis; natural product asymmetric cyclization; substrate-controlled manner; total synthesis; natural product

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jo, J.; Kim, S.-H.; Han, Y.T.; Kwak, J.-H.; Yun, H. Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis. Molecules 2017, 22, 1069.

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