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Molecules 2017, 22(7), 1042; doi:10.3390/molecules22071042

Antibacterial Effect of a 4x Cu-TiO2 Coating Simulating Acute Periprosthetic Infection—An Animal Model

Department of Trauma and Orthopaedic Surgery, St. Theresa-Hospital Nuremberg, Mommsenstr. 24, 90491 Nuremberg, Germany
Biomechanics Laboratory-UO Lab, Department of Trauma and Orthopedic Surgery, University Hospital Erlangen Krankenhausstr. 12, 91054 Erlangen, Germany
Abteilung für Unfall-, Hand-, und Orthopädische Chirurgie, Sana Kliniken Solln Sendling, Plinganserstraße 122, 81369 München, Germany
Department of Trauma and Orthopedic Surgery, University Hospital Erlangen, Krankenhausstr. 12, 91054 Erlangen, Germany
Institute of Microbiology, Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen, Wasserturmstraße 35, 91054 Erlangen, Germany
BioCer Entwicklungs GmbH, Ludwig-Thoma-Straße 36, 95447 Bayreuth, Germany
Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-University Erlangen-Nuremberg, Waldstr.6, 91054 Erlangen, Germany
Department of Orthopaedic Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Rathsbergerstr. 54, 91054 Erlangen, Germany
Author to whom correspondence should be addressed.
Received: 23 May 2017 / Revised: 20 June 2017 / Accepted: 20 June 2017 / Published: 23 June 2017
(This article belongs to the Special Issue Antibacterial Materials and Coatings)
View Full-Text   |   Download PDF [2617 KB, uploaded 26 June 2017]   |  


The purpose of our study was to investigate the antibacterial effect of a spacer (Ti6Al4V) coated with 4x Cu-TiO2 in an animal model simulating an acute periprosthetic infection by Staphylococcus aureus. Ti6Al4 bolts contaminated with Staphylococcus aureus were implanted into the femoral condyle of rabbits (n = 36) divided into 3 groups. After one week in group 1 (control) the bolts were removed without any replacement. In group2 Ti6Al4V bolts with a 4x Cu-TiO2 coating and in group 3 beads of a gentamicin-PMMA chain were imbedded into the borehole. Microbiological investigation was performed at the primary surgery, at the revision surgery and after scarification of the rabbits 3 weeks after the first surgery. Blood tests were conducted weekly. The initial overall infection rate was 88.9%. In group 2 and 3 a significant decrease of the infection rate was shown in contrast to the control group. The C-reactive protein (CRP) levels declined one week after the first surgery except in the control group where the CRP level even increased. This is the first in vivo study that demonstrated the antibacterial effects of a fourfold Cu-TiO2 coating. For the future, the coating investigated could be a promising option in the treatment of implant-associated infections. View Full-Text
Keywords: antibacterial Cu-TiO2 coating; acute implant-associated infection; animal model; total knee arthroplasty; copper-ions antibacterial Cu-TiO2 coating; acute implant-associated infection; animal model; total knee arthroplasty; copper-ions

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mauerer, A.; Stenglein, S.; Schulz-Drost, S.; Schoerner, C.; Taylor, D.; Krinner, S.; Heidenau, F.; Adler, W.; Forst, R. Antibacterial Effect of a 4x Cu-TiO2 Coating Simulating Acute Periprosthetic Infection—An Animal Model. Molecules 2017, 22, 1042.

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