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Molecules 2017, 22(6), 948; doi:10.3390/molecules22060948

Two New β-Dihydroagarofuran Sesquiterpenes from Celastrus orbiculatus Thunb and Their Anti-Proliferative Activity

1
Department of Pharmacognosy and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
2
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 May 2017 / Revised: 5 June 2017 / Accepted: 5 June 2017 / Published: 9 June 2017
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Abstract

Two new β-dihydroagarofuran-type sesquiterpenes (12) were isolated and identified from the fruit of Celastrus orbiculatus Thunb, together with seventeen known compounds (319). The structures of the isolated new compounds were elucidated based on extensive spectroscopic analyses. The cytotoxic activities of the 19 sesquiterpenes on three cell lines, human acute promyelocytic leukemia HL-60, human leukemic K562, and human colon cancer HCT-116 cells, were evaluated in vitro. Compound 4 exhibited potent cytotoxic activity against HL-60, K562, and HCT116 cell lines with IC50 values of 3.61 μΜ, 17.13 μΜ and 10.15 μΜ, respectively, and the other compounds displayed moderate activity. View Full-Text
Keywords: Celastrus orbiculatus Thunb; β-dihydroagarofuran-type sesquiterpene; anti-proliferative Celastrus orbiculatus Thunb; β-dihydroagarofuran-type sesquiterpene; anti-proliferative
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhou, J.; Han, N.; Lv, G.; Jia, L.; Liu, Z.; Yin, J. Two New β-Dihydroagarofuran Sesquiterpenes from Celastrus orbiculatus Thunb and Their Anti-Proliferative Activity. Molecules 2017, 22, 948.

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