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Molecules 2017, 22(6), 930; doi:10.3390/molecules22060930

Laurus nobilis: Composition of Essential Oil and Its Biological Activities

1
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano (Salerno), Italy
2
Istituto di Scienze dell’Alimentazione, Consiglio Nazionale delle Ricerche (ISA-CNR), Via Roma 64, 83100 Avellino, Italy
3
Post-Doctoral by National Counsel of Technological and Scientific Development (CNPq/Brazil), 70000-000 Brasília, Brazil
4
Dipartimento di Agricoltura, Ambiente e Alimenti-Università del Molise, Via de Sanctis snc, 86100 Campobasso, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Olga Tzakou
Received: 10 May 2017 / Revised: 30 May 2017 / Accepted: 1 June 2017 / Published: 3 June 2017
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
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Abstract

Laurus nobilis is native to the southern Mediterranean region and cultivated mainly in Europe and the USA as an ornamental and medicinal plant. The chemical composition of the essential oil (EO) from leaves of L. nobilis, collected in Southern Italy, was studied by GC and GC-MS. In all, 55 compounds were identified, accounting for 91.6% of the total oil. 1,8-Cineole (31.9%), sabinene (12.2%), and linalool (10.2%) were the main components. Antimicrobial and antifungal activities of EO and 1,8-cineole were determined in vitro. The cytotoxicity of the EO was evaluated against SH-SY5Y cell line, as well as the influence of the EO on the expression of adenylate cyclase 1 (ADCY1), suggesting possible oil effects on the Central Nervous System. View Full-Text
Keywords: Laurus nobilis L.; essential oil; antibacterial activity; antifungal activity; cytotoxicity; adenylate cyclase 1 (ADCY1); Central Nervous System (CNS) Laurus nobilis L.; essential oil; antibacterial activity; antifungal activity; cytotoxicity; adenylate cyclase 1 (ADCY1); Central Nervous System (CNS)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Caputo, L.; Nazzaro, F.; Souza, L.F.; Aliberti, L.; De Martino, L.; Fratianni, F.; Coppola, R.; De Feo, V. Laurus nobilis: Composition of Essential Oil and Its Biological Activities. Molecules 2017, 22, 930.

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