Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases
AbstractCardiovascular diseases remain the number one diseases affecting patients’ morbidity and mortality. The adenosine receptors are G-protein coupled receptors which have been of interest for drugs target for the treatment of multiple diseases ranging from cardiovascular to neurological. Adenosine receptors have been connected to several biological pathways affecting the physiology and pathology of the cardiovascular system. In this review, we will cover the different adenosine receptor ligands that have been identified to interact with adenosine receptors and affect the vascular system. These ligands will be evaluated from clinical as well as medicinal chemistry perspectives with more emphasis on how structural changes in structure translate into ligand potency and efficacy. Adenosine receptors represent a novel therapeutic target for development of treatment options treating a wide variety of diseases, including vascular disease and obesity. View Full-Text
Share & Cite This Article
Geldenhuys, W.J.; Hanif, A.; Yun, J.; Nayeem, M.A. Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases. Molecules 2017, 22, 917.
Geldenhuys WJ, Hanif A, Yun J, Nayeem MA. Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases. Molecules. 2017; 22(6):917.Chicago/Turabian Style
Geldenhuys, Werner J.; Hanif, Ahmad; Yun, June; Nayeem, Mohammed A. 2017. "Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases." Molecules 22, no. 6: 917.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.