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Molecules 2017, 22(6), 904; doi:10.3390/molecules22060904

Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid

1
Holy Stone Healthcare Co., Ltd., Taipei 11493, Taiwan
2
Division of Animal Resource, Animal Technology Laboratories, Agricultural Technology Research Institute, Hsinchu City 30093, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Muraleedharan G. Nair
Received: 21 April 2017 / Revised: 26 May 2017 / Accepted: 28 May 2017 / Published: 30 May 2017
(This article belongs to the Special Issue Anti-inflammatory Agents)
View Full-Text   |   Download PDF [3024 KB, uploaded 1 June 2017]   |  

Abstract

Drugs such as mesalamine (5-ASA) are currently recommended for the treatment of inflammatory bowel disease (IBD). To reduce the frequency of their administration and improve their therapeutic effect, this study investigated the adhesion efficacy, wound healing promotion, and decrease in inflammation in ulcers in the colonic tissue of rats with colitis after combined treatment with hyaluronic acid (HA) and 5-ASA (IBD98-M). HA-fluoresceinamine (FL) conjugates successfully adhered to the mucosal layer and were conjugated in the vascular tissue. In addition, macroscopic and microscopic observations indicated that colonic injuries reduced significantly after treatment with IBD98-M. Compared with PBS and 5-ASA treatment alone, treatment with IBD98-M more effectively reduced bowel inflammation and promoted colonic mucosal healing in TNBS-induced colitis. IBD98-M treatment also reduced myeloperoxidase activity and the expression levels of cyclooxygenase 2 and tumor necrosis factor-αin the colitis tissue. In conclusion, IBD98-M treatment strongly promoted wound healing in colonic injuries and significantly inhibited MPO activity in the inflamed colon tissue of rats. Combined treatment with HA and 5-ASA can accelerate wound healing and reduce inflammatory reaction in rat colitis. View Full-Text
Keywords: colitis; hyaluronic acid; inflammatory bowel disease; mucosal healing; remission colitis; hyaluronic acid; inflammatory bowel disease; mucosal healing; remission
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chiu, C.-T.; Kuo, S.-N.; Hung, S.-W.; Yang, C.-Y. Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid. Molecules 2017, 22, 904.

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