Anti-Inflammatory Activity of a Polymeric Proanthocyanidin from Serjania schiedeana
AbstractThe ethyl acetate extract (SsAcOEt) from Serjania schiedeana, select fractions (F-6, F-12, F-13, F-14), and one isolated compound, were evaluated in 12-O-tetradecanoylphorbol 13-acetate (TPA) ear edema and kaolin/carrageenan (KC)-induced monoarthritis assays. SsEtOAc induced edema inhibition of 90% (2.0 mg/ear), fractions showed activity within a range of 67–89%. Due to the fact F-14 showed the highest effect, it was separated, yielding a proanthocyanidin-type called epicatechin–(4β → 8)–epicatechin–(4β → 8, 2β → O → 7) epicatechin (ETP). This compound (2.0 mg/ear) provoked 72% of edema inhibition (ED50 = 0.25 mg/ear, Emax = 52.9%). After 9 days of treatment, joint inflammation was decreasing, and on the last day, SsEtOAc (400 mg/kg), F-14 and ETP (10 mg/kg), SsEtOAc (200 mg/kg), methotrexate (MTX) 1.0 mg/kg and meloxicam (MEL) 1.5 mg/kg, produced an inhibition articulate edema of 94, 62, 36, 21, 80, and 54%, respectively. In the joint, pro-inflammatory molecules were elevated in animals without treatment (vehicle group, VEH). Treatments from S. schiedeana induced a decrease in the concentration of interleukin (IL)-1β, IL-17, and IL-6, and SsEtOAc at a higher dose diminished tumor necrosis factor (TNF-α). IL-10 and IL-4 were fewer in the VEH group in comparison with healthy mice; the animals with treatments from S. schiedeana induced an increment in the levels of these cytokines in joint and spleen. View Full-Text
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Salinas-Sánchez, D.O.; Jiménez-Ferrer, E.; Sánchez-Sánchez, V.; Zamilpa, A.; González-Cortazar, M.; Tortoriello, J.; Herrera-Ruiz, M. Anti-Inflammatory Activity of a Polymeric Proanthocyanidin from Serjania schiedeana. Molecules 2017, 22, 863.
Salinas-Sánchez DO, Jiménez-Ferrer E, Sánchez-Sánchez V, Zamilpa A, González-Cortazar M, Tortoriello J, Herrera-Ruiz M. Anti-Inflammatory Activity of a Polymeric Proanthocyanidin from Serjania schiedeana. Molecules. 2017; 22(6):863.Chicago/Turabian Style
Salinas-Sánchez, David O.; Jiménez-Ferrer, Enrique; Sánchez-Sánchez, Veronica; Zamilpa, Alejandro; González-Cortazar, Manasés; Tortoriello, Jaime; Herrera-Ruiz, Maribel. 2017. "Anti-Inflammatory Activity of a Polymeric Proanthocyanidin from Serjania schiedeana." Molecules 22, no. 6: 863.
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