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Molecules 2017, 22(6), 1002; doi:10.3390/molecules22061002

Identification of Onosma visianii Roots Extract and Purified Shikonin Derivatives as Potential Acaricidal Agents against Tetranychus urticae

1
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo, 35121 Padova, Italy
2
Crop Research Institute, Drnovska 507, 161 06, Prague 6, Czech Republic
3
Department of Botany, Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Mánesova 23, 04154 Košice, Slovakia
4
School of Pharmacy, University of Camerino, Via Sant’Agostino 1, 62032 Camerino, Italy
5
Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy
These authors contributed equally to the work.
*
Authors to whom correspondence should be addressed.
Received: 11 May 2017 / Revised: 13 June 2017 / Accepted: 14 June 2017 / Published: 16 June 2017
(This article belongs to the Section Natural Products)
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Abstract

There is an increasing need for the discovery of reliable and eco-friendly pesticides and natural plant-derived products may play a crucial role as source of new active compounds. In this research, a lipophilic extract of Onosma visianii roots extract containing 12% of shikonin derivatives demonstrated significant toxicity and inhibition of oviposition against Tetranychus urticae mites. Extensive chromatographic separation allowed the isolation of 11 naphthoquinone derivatives that were identified by spectral techniques and were tested against Tetranychus urticae. All the isolated compounds presented effects against the considered mite and isobutylshikonin (1) and isovalerylshikonin (2) were the most active, being valuable model compounds for the study of new anti-mite agents. View Full-Text
Keywords: biopesticide; eco-friendly insecticide; Tetranychus urticae; Onosma visianii; shikonin derivatives biopesticide; eco-friendly insecticide; Tetranychus urticae; Onosma visianii; shikonin derivatives
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sut, S.; Pavela, R.; Kolarčik, V.; Cappellacci, L.; Petrelli, R.; Maggi, F.; Dall’Acqua, S.; Benelli, G. Identification of Onosma visianii Roots Extract and Purified Shikonin Derivatives as Potential Acaricidal Agents against Tetranychus urticae. Molecules 2017, 22, 1002.

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