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Molecules 2017, 22(5), 842; doi:10.3390/molecules22050842

Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.

College of Medicine, Henan Polytechnic University, Jiaozuo 454000, China
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 March 2017 / Revised: 12 May 2017 / Accepted: 13 May 2017 / Published: 19 May 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [889 KB, uploaded 19 May 2017]   |  


Three new abietane-type diterpenoids, named callicapoic acid M3 (1), callicapoic acid M4 (2) and callicapoic acid M5 (3), were isolated from the Callicarpa macrophylla Vahl. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). All the isolated three compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1, 2 and 3 showed potent inhibitory activity, with inhibition rates of 34.47–40.13%. View Full-Text
Keywords: Callicarpa macrophylla Vahl.; abietane-type diterpenoids; NMR; anti-inflammatory activity Callicarpa macrophylla Vahl.; abietane-type diterpenoids; NMR; anti-inflammatory activity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, Z.-H.; Niu, C.; Zhou, D.-J.; Kong, J.-C.; Zhang, W.-K. Three New Abietane-Type Diterpenoids from Callicarpa macrophylla Vahl.. Molecules 2017, 22, 842.

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